Version 5.4
Homo sapiens Protein: DNAJB11
Summary
InnateDB Protein IDBP-68898.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAJB11
Protein Name DnaJ (Hsp40) homolog, subfamily B, member 11
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000265028
InnateDB Gene IDBG-68896 (DNAJB11)
Protein Structure
UniProt Annotation
Function Serves as a co-chaperone for HSPA5. Binds directly to both unfolded proteins that are substrates for ERAD and nascent unfolded peptide chains, but dissociates from the HSPA5-unfolded protein complex before folding is completed. May help recruiting HSPA5 and other chaperones to the substrate. Stimulates HSPA5 ATPase activity. {ECO:0000269PubMed:10827079, ECO:0000269PubMed:15525676}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000269PubMed:10827079, ECO:0000269PubMed:15195998, ECO:0000269PubMed:15525676, ECO:0000269PubMed:15544163}. Note=Associated with the ER membrane in a C-terminally epitope- tagged construct.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:10827079, ECO:0000269PubMed:11584023, ECO:0000269PubMed:15525676}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 79 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 79 [view]
Protein-Protein 77 [view]
Protein-DNA 1 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
GO:0006987 activation of signaling protein activity involved in unfolded protein response
GO:0030968 endoplasmic reticulum unfolded protein response
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR001623 DnaJ domain
IPR002939 Chaperone DnaJ, C-terminal
IPR008971 HSP40/DnaJ peptide-binding
PFAM PF00226
PF01556
PRINTS PR00625
PIRSF
SMART SM00271
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9UBS4
PhosphoSite PhosphoSite-Q9UBS4
TrEMBL B3KW63
UniProt Splice Variant
Entrez Gene 51726
UniGene Hs.738892
RefSeq NP_057390
HUGO HGNC:14889
OMIM 611341
CCDS CCDS3277
HPRD 07485
IMGT
EMBL AB028859 AF228505 AF277317 AJ250137 AK075300 AK075430 AK124289 AK301292 AY359043 BC001144 BT007063 CH471052 CR457096
GenPept AAF61711 AAH01144 AAK69110 AAP35712 AAQ89402 BAA88307 BAC11533 BAC11617 BAG54025 BAG62850 CAB65118 CAG33377 EAW78190

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca