Version 5.4
Bos taurus Protein: TPK1
Summary
InnateDB Protein IDBP-689035.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TPK1
Protein Name Thiamin pyrophosphokinase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000023510
InnateDB Gene IDBG-637058 (TPK1)
Protein Structure
UniProt Annotation
Function Catalyzes the phosphorylation of thiamine to thiamine pyrophosphate. Can also catalyze the phosphorylation of pyrithiamine to pyrithiamine pyrophosphate (By similarity). {ECO:0000250}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004788 thiamine diphosphokinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0030975 thiamine binding
Biological Process
GO:0006772 thiamine metabolic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0016310 phosphorylation
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR006282 Thiamin pyrophosphokinase
IPR007371 Thiamin pyrophosphokinase, catalytic domain
IPR007373 Thiamin pyrophosphokinase, vitamin B1-binding domain
IPR016966 Thiamin pyrophosphokinase, eukaryotic
PFAM PF04263
PF04265
PRINTS
PIRSF PIRSF031057
SMART SM00983
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9T4
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 788066
UniGene Bt.6512
RefSeq NP_001073839
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC119895 BT020836
GenPept AAI19896 AAX08853

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca