InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: IL12A

Summary

InnateDB Protein

IDBP-689087.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL12A

Protein Name

Interleukin-12 subunit alpha

Synonyms

Il-12 p35; IL12p35;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000020153

InnateDB Gene

IDBG-637103 (IL12A)

Protein Structure

UniProt Annotation

Function

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine- activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. {ECO:0000250}.

Subcellular Localization

Secreted.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.

Predicted by orthology
Total	21 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0005143	interleukin-12 receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity
GO:0042163	interleukin-12 beta subunit binding
GO:0045513	interleukin-27 binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0001916	positive regulation of T cell mediated cytotoxicity
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
GO:0006955	immune response
GO:0007050	cell cycle arrest
GO:0009615	response to virus
GO:0010224	response to UV-B
GO:0016477	cell migration
GO:0030101	natural killer cell activation
GO:0032496	response to lipopolysaccharide
GO:0032700	negative regulation of interleukin-17 production
GO:0032729	positive regulation of interferon-gamma production
GO:0032816	positive regulation of natural killer cell activation
GO:0032946	positive regulation of mononuclear cell proliferation
GO:0034393	positive regulation of smooth muscle cell apoptotic process
GO:0042093	T-helper cell differentiation
GO:0042095	interferon-gamma biosynthetic process
GO:0042102	positive regulation of T cell proliferation
GO:0042104	positive regulation of activated T cell proliferation
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein
GO:0042832	defense response to protozoan
GO:0045582	positive regulation of T cell differentiation
GO:0045785	positive regulation of cell adhesion
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0048662	negative regulation of smooth muscle cell proliferation
GO:0050671	positive regulation of lymphocyte proliferation
GO:0050830	defense response to Gram-positive bacterium
GO:0051135	positive regulation of NK T cell activation
GO:0097191	extrinsic apoptotic signaling pathway

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0043514	interleukin-12 complex

Protein Structure and Domains

PDB ID

InterPro

IPR004281 Interleukin-12 alpha
IPR009079 Four-helical cytokine-like, core

PFAM

PF03039

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P54349

PhosphoSite

PhosphoSite-

TrEMBL

Q9MYW1

UniProt Splice Variant

Entrez Gene

281856

UniGene

RefSeq

NP_776780

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AJ271034 EU276075 U14416

GenPept

AAA85810 ABX72073 CAB97049