InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CCBL2

Summary

InnateDB Protein

IDBP-689113.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCBL2

Protein Name

Kynurenine--oxoglutarate transaminase 3

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000643

InnateDB Gene

IDBG-637116 (CCBL2)

Protein Structure

UniProt Annotation

Function

Catalyzes the irreversible transamination of the L- tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se- conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2- oxoglutarate as amino group acceptor (in vitro) (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0008483	transaminase activity
GO:0016212	kynurenine-oxoglutarate transaminase activity
GO:0016740	transferase activity
GO:0016829	lyase activity
GO:0030170	pyridoxal phosphate binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding
GO:0047315	kynurenine-glyoxylate transaminase activity
GO:0047804	cysteine-S-conjugate beta-lyase activity

Biological Process

GO:0006103	2-oxoglutarate metabolic process
GO:0006520	cellular amino acid metabolic process
GO:0009058	biosynthetic process
GO:0070189	kynurenine metabolic process
GO:0097052	L-kynurenine metabolic process

Cellular Component

GO:0005739

mitochondrion

Protein Structure and Domains

PDB ID

InterPro

IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00155

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q0P5G4

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

508712

UniGene

Bt.40115

RefSeq

NP_001068838

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC120067

GenPept

AAI20068