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InnateDB Protein
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IDBP-689142.3
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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PARPBP
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Protein Name
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chromosome 12 open reading frame 48
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Synonyms
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C5H12orf48; PARI;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000053842
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InnateDB Gene
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IDBG-637144 (PARPBP)
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Protein Structure
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| Function |
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP- ribosyl)ation activity of PARP1; however such function may be indirect (By similarity). {ECO:0000250}.
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| Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Localizes to chromatin in response to S phase arrest but not in mitosis. Targeted to chromatin via its interaction with PCNA (By similarity). {ECO:0000250}.
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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| Biological Process |
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GO:0006281
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DNA repair
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GO:0006974
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cellular response to DNA damage stimulus
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GO:2000042
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negative regulation of double-strand break repair via homologous recombination
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| Cellular Component |
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| PDB ID |
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| InterPro |
IPR027417
P-loop containing nucleoside triphosphate hydrolase
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| PFAM |
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| PRINTS |
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| PIRSF |
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
F1MF21
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| PhosphoSite |
PhosphoSite-
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| TrEMBL |
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| UniProt Splice Variant |
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| Entrez Gene |
615510
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| UniGene |
Bt.40622
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| RefSeq |
XP_002687684
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| HUGO |
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
DAAA02013696
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| GenPept |
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Version 5.4