InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: MAP4K1

Summary

InnateDB Protein

IDBP-689178.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MAP4K1

Protein Name

mitogen-activated protein kinase kinase kinase kinase 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000028180

InnateDB Gene

IDBG-637177 (MAP4K1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008349	MAP kinase kinase kinase kinase activity
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0006950	response to stress
GO:0008283	cell proliferation
GO:0016310	phosphorylation
GO:0018105	peptidyl-serine phosphorylation
GO:0035556	intracellular signal transduction
GO:0046777	protein autophosphorylation
GO:0050790	regulation of catalytic activity

Cellular Component

GO:0016020

membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt