Version 5.4
Bos taurus Protein: PTEN
Summary
InnateDB Protein IDBP-689259.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTEN
Protein Name phosphatase and tensin homolog
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000012499
InnateDB Gene IDBG-637256 (PTEN)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 92 interaction(s) predicted by orthology.
Predicted by orthology
Total 92 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0004438 phosphatidylinositol-3-phosphatase activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0010997 anaphase-promoting complex binding
GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0016791 phosphatase activity
GO:0019899 enzyme binding
GO:0019901 protein kinase binding
GO:0030165 PDZ domain binding
GO:0051717 inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0051800 phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
Biological Process
GO:0001525 angiogenesis
GO:0001933 negative regulation of protein phosphorylation
GO:0002902 regulation of B cell apoptotic process
GO:0006470 protein dephosphorylation
GO:0007092 activation of mitotic anaphase-promoting complex activity
GO:0007270 neuron-neuron synaptic transmission
GO:0007416 synapse assembly
GO:0007417 central nervous system development
GO:0007507 heart development
GO:0007611 learning or memory
GO:0007626 locomotory behavior
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010975 regulation of neuron projection development
GO:0016311 dephosphorylation
GO:0016477 cell migration
GO:0021542 dentate gyrus development
GO:0021955 central nervous system neuron axonogenesis
GO:0030336 negative regulation of cell migration
GO:0031642 negative regulation of myelination
GO:0031647 regulation of protein stability
GO:0031658 negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032286 central nervous system myelin maintenance
GO:0032535 regulation of cellular component size
GO:0033032 regulation of myeloid cell apoptotic process
GO:0033555 multicellular organismal response to stress
GO:0035176 social behavior
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0042711 maternal behavior
GO:0043066 negative regulation of apoptotic process
GO:0043491 protein kinase B signaling
GO:0043542 endothelial cell migration
GO:0045475 locomotor rhythm
GO:0045792 negative regulation of cell size
GO:0046621 negative regulation of organ growth
GO:0046855 inositol phosphate dephosphorylation
GO:0046856 phosphatidylinositol dephosphorylation
GO:0048738 cardiac muscle tissue development
GO:0048853 forebrain morphogenesis
GO:0048854 brain morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050771 negative regulation of axonogenesis
GO:0050821 protein stabilization
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726 regulation of cell cycle
GO:0051895 negative regulation of focal adhesion assembly
GO:0051898 negative regulation of protein kinase B signaling
GO:0060024 rhythmic synaptic transmission
GO:0060070 canonical Wnt signaling pathway
GO:0060074 synapse maturation
GO:0060134 prepulse inhibition
GO:0060179 male mating behavior
GO:0060291 long-term synaptic potentiation
GO:0060736 prostate gland growth
GO:0060997 dendritic spine morphogenesis
GO:0061002 negative regulation of dendritic spine morphogenesis
GO:0090071 negative regulation of ribosome biogenesis
GO:0090344 negative regulation of cell aging
GO:0090394 negative regulation of excitatory postsynaptic membrane potential
GO:0097105 presynaptic membrane assembly
GO:0097107 postsynaptic density assembly
GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:2000134 negative regulation of G1/S transition of mitotic cell cycle
GO:2000463 positive regulation of excitatory postsynaptic membrane potential
GO:2000808 negative regulation of synaptic vesicle clustering
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0009898 cytoplasmic side of plasma membrane
GO:0035749 myelin sheath adaxonal region
GO:0042995 cell projection
GO:0043005 neuron projection
GO:0043220 Schmidt-Lanterman incisure
Protein Structure and Domains
PDB ID
InterPro IPR000008 C2 domain
IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000340 Dual specificity phosphatase, catalytic domain
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR014020 Tensin phosphatase, C2 domain
IPR017361 Bifunctional phosphatidylinositol trisphosphate phosphatase/dual specificity phosphatase PTEN
IPR029021 Protein-tyrosine phosphatase-like
IPR029023 Tensin phosphatase, lipid phosphatase domain
PFAM PF00168
PF00102
PF00782
PF10409
PRINTS PR00360
PR00700
PIRSF PIRSF038025
SMART SM00239
SM00194
SM00404
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MDX9
UniProt Splice Variant
Entrez Gene 540786
UniGene
RefSeq XP_002698416
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BK008846 DAAA02058711
GenPept DAA64600

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca