Version 5.4
Bos taurus Protein: MARF1
Summary
InnateDB Protein IDBP-689272.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MARF1
Protein Name KIAA0430
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027175
InnateDB Gene IDBG-637245 (MARF1)
Protein Structure
UniProt Annotation
Function Essential regulator of oogenesis required for female meiotic progression to repress transposable elements and preventing their mobilization, which is essential for the germline integrity. Probably acts via some RNA metabolic process, equivalent to the piRNA system in males, which mediates the repression of transposable elements during meiosis by forming complexes composed of RNAs and governs the methylation and subsequent repression of transposons. Also required to protect from DNA double-strand breaks (By similarity). {ECO:0000250}.
Subcellular Localization Peroxisome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
Biological Process
GO:0006302 double-strand break repair
GO:0007126 meiotic nuclear division
GO:0007143 female meiotic division
GO:0010468 regulation of gene expression
GO:0010923 negative regulation of phosphatase activity
GO:0030154 cell differentiation
GO:0048477 oogenesis
Cellular Component
GO:0005777 peroxisome
GO:0016020 membrane
Protein Structure and Domains
PDB ID
InterPro IPR000504 RNA recognition motif domain
IPR021139 NYN domain, limkain-b1-type
IPR024582 Limkain b1, conserved domain
PFAM PF00076
PF01936
PF11608
PRINTS
PIRSF
SMART SM00360
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E1BP74
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 506615
UniGene
RefSeq NP_001258923
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02057550
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca