Version 5.4
Bos taurus Protein: DDAH1
Summary
InnateDB Protein IDBP-689283.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DDAH1
Protein Name N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000046157
InnateDB Gene IDBG-637283 (DDAH1)
Protein Structure
UniProt Annotation
Function Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation.
Subcellular Localization
Disease Associations
Tissue Specificity Widely distributed, highest concentrations found in brain, brain cortex and kidney (at protein level). {ECO:0000269PubMed:9537995}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008270 zinc ion binding
GO:0016403 dimethylargininase activity
GO:0016787 hydrolase activity
GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
GO:0046872 metal ion binding
Biological Process
GO:0000052 citrulline metabolic process
GO:0003073 regulation of systemic arterial blood pressure
GO:0006809 nitric oxide biosynthetic process
GO:0017014 protein nitrosylation
GO:0045429 positive regulation of nitric oxide biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR003198 Amidinotransferase
PFAM PF02274
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P56965
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 537391
UniGene Bt.23651
RefSeq NP_001095671
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC149998
GenPept AAI49999

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca