Version 5.4
Bos taurus Protein: BT.89249
Summary
InnateDB Protein IDBP-689298.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BT.89249
Protein Name ATP-binding cassette sub-family A member 1
Synonyms ABC-1;
Species Bos taurus
Ensembl Protein ENSBTAP00000027538
InnateDB Gene IDBG-637291 (BT.89249)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 33 interaction(s) predicted by orthology.
Predicted by orthology
Total 33 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005548 phospholipid transporter activity
GO:0008509 anion transmembrane transporter activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0017127 cholesterol transporter activity
GO:0019905 syntaxin binding
GO:0031267 small GTPase binding
GO:0034185 apolipoprotein binding
GO:0034186 apolipoprotein A-I binding
GO:0034188 apolipoprotein A-I receptor activity
GO:0051117 ATPase binding
Biological Process
GO:0002790 peptide secretion
GO:0006200 ATP catabolic process
GO:0006497 protein lipidation
GO:0006911 phagocytosis, engulfment
GO:0007040 lysosome organization
GO:0007186 G-protein coupled receptor signaling pathway
GO:0008203 cholesterol metabolic process
GO:0010875 positive regulation of cholesterol efflux
GO:0016197 endosomal transport
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032367 intracellular cholesterol transport
GO:0032489 regulation of Cdc42 protein signal transduction
GO:0033344 cholesterol efflux
GO:0033700 phospholipid efflux
GO:0034380 high-density lipoprotein particle assembly
GO:0034616 response to laminar fluid shear stress
GO:0038027 apolipoprotein A-I-mediated signaling pathway
GO:0042157 lipoprotein metabolic process
GO:0042158 lipoprotein biosynthetic process
GO:0042632 cholesterol homeostasis
GO:0043691 reverse cholesterol transport
GO:0045332 phospholipid translocation
GO:0050702 interleukin-1 beta secretion
GO:0055091 phospholipid homeostasis
GO:0055098 response to low-density lipoprotein particle stimulus
GO:0060155 platelet dense granule organization
GO:0071222 cellular response to lipopolysaccharide
GO:0071300 cellular response to retinoic acid
Cellular Component
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0009897 external side of plasma membrane
GO:0030139 endocytic vesicle
GO:0043231 intracellular membrane-bounded organelle
GO:0045121 membrane raft
GO:0045335 phagocytic vesicle
GO:0048471 perinuclear region of cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR003439 ABC transporter-like
IPR003593 AAA+ ATPase domain
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF00005
PRINTS
PIRSF
SMART SM00382
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MG24
UniProt Splice Variant
Entrez Gene 535379
UniGene Bt.89249
RefSeq NP_001019864
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02024383 DAAA02024384
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca