Version 5.4
Bos taurus Protein: HSP90B1
Summary
InnateDB Protein IDBP-689416.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol HSP90B1
Protein Name Endoplasmin
Synonyms TRA1;
Species Bos taurus
Ensembl Protein ENSBTAP00000004364
InnateDB Gene IDBG-637404 (HSP90B1)
Protein Structure
UniProt Annotation
Function Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum lumen {ECO:0000250}. Melanosome {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.
Predicted by orthology
Total 74 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0019903 protein phosphatase binding
GO:0046790 virion binding
GO:0050750 low-density lipoprotein particle receptor binding
GO:0051082 unfolded protein binding
Biological Process
GO:0001666 response to hypoxia
GO:0006457 protein folding
GO:0006950 response to stress
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0031247 actin rod assembly
GO:0043066 negative regulation of apoptotic process
GO:0043666 regulation of phosphoprotein phosphatase activity
GO:0071318 cellular response to ATP
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005788 endoplasmic reticulum lumen
GO:0005789 endoplasmic reticulum membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030496 midbody
GO:0042470 melanosome
GO:0048471 perinuclear region of cytoplasm
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001404 Heat shock protein Hsp90 family
IPR003594 Histidine kinase-like ATPase, C-terminal domain
IPR020568 Ribosomal protein S5 domain 2-type fold
IPR020575 Heat shock protein Hsp90, N-terminal
PFAM PF00183
PF02518
PF13581
PRINTS PR00775
PIRSF PIRSF002583
SMART SM00387
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q95M18
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282646
UniGene Bt.8686
RefSeq NP_777125
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB025193 BC104549
GenPept AAI04550 BAB69766

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca