Bos taurus Protein: SIRT2
Summary
InnateDB Protein IDBP-689429.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIRT2
Protein Name NAD-dependent deacetylase sirtuin-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002327
InnateDB Gene IDBG-637405 (SIRT2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 109 interaction(s) predicted by orthology.
Predicted by orthology
Total 109 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003682 chromatin binding
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017136 NAD-dependent histone deacetylase activity
GO:0033558 protein deacetylase activity
GO:0034979 NAD-dependent protein deacetylase activity
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
GO:0042903 tubulin deacetylase activity
GO:0043130 ubiquitin binding
GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0048487 beta-tubulin binding
GO:0051287 NAD binding
GO:0070403 NAD+ binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006476 protein deacetylation
GO:0008285 negative regulation of cell proliferation
GO:0010507 negative regulation of autophagy
GO:0010801 negative regulation of peptidyl-threonine phosphorylation
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0016575 histone deacetylation
GO:0021762 substantia nigra development
GO:0022011 myelination in peripheral nervous system
GO:0031641 regulation of myelination
GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034599 cellular response to oxidative stress
GO:0034983 peptidyl-lysine deacetylation
GO:0035729 cellular response to hepatocyte growth factor stimulus
GO:0042177 negative regulation of protein catabolic process
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0043388 positive regulation of DNA binding
GO:0043491 protein kinase B signaling
GO:0044242 cellular lipid catabolic process
GO:0045599 negative regulation of fat cell differentiation
GO:0045836 positive regulation of meiosis
GO:0045843 negative regulation of striated muscle tissue development
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048012 hepatocyte growth factor receptor signaling pathway
GO:0051726 regulation of cell cycle
GO:0051781 positive regulation of cell division
GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore
GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0061433 cellular response to caloric restriction
GO:0070932 histone H3 deacetylation
GO:0070933 histone H4 deacetylation
GO:0071219 cellular response to molecule of bacterial origin
GO:0071456 cellular response to hypoxia
GO:0071872 cellular response to epinephrine stimulus
GO:0090042 tubulin deacetylation
GO:1900119 positive regulation of execution phase of apoptosis
GO:1900195 positive regulation of oocyte maturation
GO:1900425 negative regulation of defense response to bacterium
GO:1901026 ripoptosome assembly involved in necroptotic process
GO:2000378 negative regulation of reactive oxygen species metabolic process
GO:2000777 positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0005737 cytoplasm
GO:0005813 centrosome
GO:0005814 centriole
GO:0005819 spindle
GO:0005829 cytosol
GO:0005874 microtubule
GO:0030496 midbody
GO:0033010 paranodal junction
GO:0043204 perikaryon
GO:0043209 myelin sheath
GO:0043220 Schmidt-Lanterman incisure
GO:0048471 perinuclear region of cytoplasm
GO:0072686 mitotic spindle
GO:0072687 meiotic spindle
Protein Structure and Domains
PDB ID
InterPro IPR003000 Sirtuin family
IPR017328 Sirtuin, class I
IPR026590 Sirtuin family, catalytic core domain
IPR029035 DHS-like NAD/FAD-binding domain
PFAM PF02146
PRINTS
PIRSF PIRSF037938
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F6QK60
UniProt Splice Variant
Entrez Gene 504463
UniGene Bt.19604
RefSeq NP_001107003
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047041 GQ166648
GenPept ACS66698