InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BCR

Summary

InnateDB Protein

IDBP-689436.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BCR

Protein Name

breakpoint cluster region

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000029392

InnateDB Gene

IDBG-637321 (BCR)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 62 interaction(s) predicted by orthology.

Predicted by orthology
Total	62 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0030675	Rac GTPase activator activity

Biological Process

GO:0007165	signal transduction
GO:0007420	brain development
GO:0030036	actin cytoskeleton organization
GO:0030336	negative regulation of cell migration
GO:0032496	response to lipopolysaccharide
GO:0032855	positive regulation of Rac GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0042472	inner ear morphogenesis
GO:0043314	negative regulation of neutrophil degranulation
GO:0050728	negative regulation of inflammatory response
GO:0050766	positive regulation of phagocytosis
GO:0050885	neuromuscular process controlling balance
GO:0051726	regulation of cell cycle

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000198 Rho GTPase-activating protein domain
IPR000219 Dbl homology (DH) domain
IPR001849 Pleckstrin homology domain
IPR008936 Rho GTPase activation protein

PFAM

PF00168
PF00620
PF00621
PF00169

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00324
SM00325
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt