InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PRKACB

Summary

InnateDB Protein

IDBP-689449.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PRKACB

Protein Name

cAMP-dependent protein kinase catalytic subunit beta

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000046803

InnateDB Gene

IDBG-637426 (PRKACB)

Protein Structure

UniProt Annotation

Function

Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, and differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:10684253}. Cell membrane {ECO:0000250}. Nucleus {ECO:0000269PubMed:10684253}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm.

Disease Associations

Tissue Specificity

Isoform 2 is mainly expressed in heart and brain. {ECO:0000269PubMed:2002051}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0000287	magnesium ion binding
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004691	cAMP-dependent protein kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0031625	ubiquitin protein ligase binding

Biological Process

GO:0001843	neural tube closure
GO:0006468	protein phosphorylation
GO:0016310	phosphorylation
GO:0070613	regulation of protein processing
GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome
GO:0097546	ciliary base

Protein Structure and Domains

PDB ID

InterPro

IPR000719 Protein kinase domain
IPR000961 AGC-kinase, C-terminal
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00133
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P05131

PhosphoSite

PhosphoSite-P05131

TrEMBL

UniProt Splice Variant

Entrez Gene

282323

UniGene

Bt.69152

RefSeq

XP_005204430

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

J02647 M60482

GenPept

AAA30424 AAA30707