InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: BT.101023

Summary

InnateDB Protein

IDBP-689457.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BT.101023

Protein Name

E3 ubiquitin-protein ligase HUWE1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000008060

InnateDB Gene

IDBG-637421 (BT.101023)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 50 interaction(s) predicted by orthology.

Predicted by orthology
Total	50 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005488	binding
GO:0005515	protein binding
GO:0016874	ligase activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000209	protein polyubiquitination
GO:0006284	base-excision repair
GO:0006513	protein monoubiquitination
GO:0016574	histone ubiquitination

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR000569 HECT
IPR004170 WWE domain
IPR009060 UBA-like
IPR010309 E3 ubiquitin ligase, domain of unknown function DUF908
IPR010314 E3 ubiquitin ligase, domain of unknown function DUF913
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR016024 Armadillo-type fold

PFAM

PF00627
PF00632
PF02825
PF06012
PF06025

PRINTS

PIRSF

SMART

SM00119
SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite