InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: FGD1

Summary

InnateDB Protein

IDBP-689569.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

FGD1

Protein Name

FYVE, RhoGEF and PH domain-containing protein 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000021084

InnateDB Gene

IDBG-637545 (FGD1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005089	Rho guanyl-nucleotide exchange factor activity
GO:0005515	protein binding
GO:0031267	small GTPase binding
GO:0046872	metal ion binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0008360	regulation of cell shape
GO:0030036	actin cytoskeleton organization
GO:0032321	positive regulation of Rho GTPase activity
GO:0035023	regulation of Rho protein signal transduction
GO:0043088	regulation of Cdc42 GTPase activity
GO:0043547	positive regulation of GTPase activity
GO:0046847	filopodium assembly

Cellular Component

GO:0001726	ruffle
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0030027	lamellipodium

Protein Structure and Domains

PDB ID

InterPro

IPR000219 Dbl homology (DH) domain
IPR000306 FYVE zinc finger
IPR001849 Pleckstrin homology domain
IPR011011 Zinc finger, FYVE/PHD-type
IPR017455 Zinc finger, FYVE-related

PFAM

PF00621
PF01363
PF00169

PRINTS

PIRSF

SMART

SM00325
SM00064
SM00233

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite