InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GNL3L

Summary

InnateDB Protein

IDBP-689573.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GNL3L

Protein Name

Guanine nucleotide-binding protein-like 3-like protein

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000004772

InnateDB Gene

IDBG-637550 (GNL3L)

Protein Structure

UniProt Annotation

Function

Stabilizes TERF1 telomeric association by preventing TERF1 recruitment by PML. Stabilizes TERF1 protein by preventing its ubiquitination and hence proteasomal degradation. Does so by interfering with TERF1-binding to FBXO4 E3 ubiquitin-protein ligase. Required for cell proliferation. By stabilizing TRF1 protein during mitosis, promotes metaphase-to-anaphase transition. Stabilizes MDM2 protein by preventing its ubiquitination, and hence proteasomal degradation. By acting on MDM2, may affect TP53 activity. Required for normal processing of ribosomal pre-rRNA. Binds GTP (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0015093	ferrous iron transmembrane transporter activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006184	GTP catabolic process
GO:0015684	ferrous iron transport
GO:0042254	ribosome biogenesis

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006073 GTP binding domain
IPR011619 Ferrous iron transport protein B, N-terminal
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF01926
PF02421

PRINTS

PR00326

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3T0J9

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

507679

UniGene

Bt.56290

RefSeq

NP_001029479

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC102363

GenPept

AAI02364