Version 5.4
Bos taurus Protein: ZFP36
Summary
InnateDB Protein IDBP-689584.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZFP36
Protein Name tristetraproline
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000055077
InnateDB Gene IDBG-637562 (ZFP36)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003729 mRNA binding
GO:0005515 protein binding
GO:0017091 AU-rich element binding
GO:0019901 protein kinase binding
GO:0019957 C-C chemokine binding
GO:0035925 mRNA 3'-UTR AU-rich region binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0071889 14-3-3 protein binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000288 nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006402 mRNA catabolic process
GO:0032680 regulation of tumor necrosis factor production
GO:0035278 negative regulation of translation involved in gene silencing by miRNA
GO:0035556 intracellular signal transduction
GO:0042594 response to starvation
GO:0043488 regulation of mRNA stability
GO:0045638 negative regulation of myeloid cell differentiation
GO:0050728 negative regulation of inflammatory response
GO:0050779 RNA destabilization
GO:0060213 positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:0070935 3'-UTR-mediated mRNA stabilization
GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0010494 cytoplasmic stress granule
Protein Structure and Domains
PDB ID
InterPro IPR000571 Zinc finger, CCCH-type
PFAM PF00642
PRINTS
PIRSF
SMART SM00356
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q0VCR3
UniProt Splice Variant
Entrez Gene 282127
UniGene Bt.3863
RefSeq
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC120043 DAAA02047055 DAAA02047056 DAAA02047057
GenPept AAI20044

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca