InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PFKFB1

Summary

InnateDB Protein

IDBP-689602.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PFKFB1

Protein Name

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000000198

InnateDB Gene

IDBG-637557 (PFKFB1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0003873	6-phosphofructo-2-kinase activity
GO:0004331	fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity

Biological Process

GO:0006000	fructose metabolic process
GO:0006003	fructose 2,6-bisphosphate metabolic process
GO:0008152	metabolic process
GO:0016311	dephosphorylation
GO:0046835	carbohydrate phosphorylation

Cellular Component

GO:0043540

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex

Protein Structure and Domains

PDB ID

InterPro

IPR003094 Fructose-2,6-bisphosphatase
IPR010488 Zeta toxin domain
IPR013078 Histidine phosphatase superfamily, clade-1
IPR013079 6-phosphofructo-2-kinase
IPR016260 Bifunctional 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphate 2-phosphatase
IPR027417 P-loop containing nucleoside triphosphate hydrolase
IPR029033 Histidine phosphatase superfamily

PFAM

PF06414
PF00300
PF01591

PRINTS

PR00991

PIRSF

PIRSF000709

SMART

SM00855

TIGRFAMs

Post-translational Modifications

Modification

Cross-References