InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: APEX2

Summary

InnateDB Protein

IDBP-689614.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

APEX2

Protein Name

DNA-(apurinic or apyrimidinic site) lyase 2

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000017537

InnateDB Gene

IDBG-637589 (APEX2)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003906	DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004518	nuclease activity
GO:0004519	endonuclease activity
GO:0008270	zinc ion binding
GO:0008311	double-stranded DNA 3'-5' exodeoxyribonuclease activity

Biological Process

GO:0000737	DNA catabolic process, endonucleolytic
GO:0000738	DNA catabolic process, exonucleolytic
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0090305	nucleic acid phosphodiester bond hydrolysis

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane

Protein Structure and Domains

PDB ID

InterPro

IPR004808 AP endonuclease 1
IPR005135 Endonuclease/exonuclease/phosphatase
IPR010666 Zinc finger, GRF-type

PFAM

PF03372
PF14529
PF06839

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

F1MSK4

UniProt Splice Variant

Entrez Gene

511790

UniGene

Bt.1184

RefSeq

NP_001015577

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

DAAA02073320 DAAA02073321

GenPept