InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: HHEX

Summary

InnateDB Protein

IDBP-689635.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HHEX

Protein Name

hematopoietically expressed homeobox

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000018899

InnateDB Gene

IDBG-637611 (HHEX)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0008190	eukaryotic initiation factor 4E binding
GO:0008301	DNA binding, bending
GO:0042803	protein homodimerization activity
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0070491	repressing transcription factor binding
GO:0071837	HMG box domain binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001570	vasculogenesis
GO:0001701	in utero embryonic development
GO:0001889	liver development
GO:0002009	morphogenesis of an epithelium
GO:0002573	myeloid leukocyte differentiation
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006406	mRNA export from nucleus
GO:0007165	signal transduction
GO:0007492	endoderm development
GO:0008283	cell proliferation
GO:0009887	organ morphogenesis
GO:0009952	anterior/posterior pattern specification
GO:0016973	poly(A)+ mRNA export from nucleus
GO:0022027	interkinetic nuclear migration
GO:0030097	hemopoiesis
GO:0030177	positive regulation of Wnt signaling pathway
GO:0030183	B cell differentiation
GO:0030878	thyroid gland development
GO:0030900	forebrain development
GO:0031016	pancreas development
GO:0034504	protein localization to nucleus
GO:0035050	embryonic heart tube development
GO:0035264	multicellular organism growth
GO:0042127	regulation of cell proliferation
GO:0045736	negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048568	embryonic organ development
GO:0048729	tissue morphogenesis
GO:0048853	forebrain morphogenesis
GO:0060431	primary lung bud formation
GO:0061009	common bile duct development
GO:0061010	gall bladder development
GO:0061011	hepatic duct development
GO:0061017	hepatoblast differentiation
GO:0070365	hepatocyte differentiation
GO:0071103	DNA conformation change
GO:0090009	primitive streak formation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0032993	protein-DNA complex

Protein Structure and Domains

PDB ID

InterPro

IPR001356 Homeobox domain
IPR009057 Homeodomain-like
IPR020479 Homeodomain, metazoa

PFAM

PF00046

PRINTS

PR00024

PIRSF

SMART

SM00389

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

A7YWK1

UniProt Splice Variant

Entrez Gene

539542

UniGene

Bt.27920

RefSeq

NP_001098894

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC134632 DAAA02058821

GenPept

AAI34633