InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: SERP1

Summary

InnateDB Protein

IDBP-689729.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERP1

Protein Name

Stress-associated endoplasmic reticulum protein 1

Synonyms

RAMP4-2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000012000

InnateDB Gene

IDBG-637701 (SERP1)

Protein Structure

UniProt Annotation

Function

Interacts with target proteins during their translocation into the lumen of the endoplasmic reticulum. Protects unfolded target proteins against degradation during ER stress. May facilitate glycosylation of target proteins after termination of ER stress. May modulate the use of N-glycosylation sites on target proteins (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane; Single-pass type IV membrane protein. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.

Predicted by orthology
Total	12 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001501	skeletal system development
GO:0006006	glucose metabolic process
GO:0006810	transport
GO:0009791	post-embryonic development
GO:0010259	multicellular organismal aging
GO:0015031	protein transport
GO:0030968	endoplasmic reticulum unfolded protein response
GO:0032024	positive regulation of insulin secretion
GO:0045727	positive regulation of translation
GO:0046622	positive regulation of organ growth
GO:0048644	muscle organ morphogenesis
GO:0060124	positive regulation of growth hormone secretion

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005881	cytoplasmic microtubule
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR010580 Stress-associated endoplasmic reticulum protein

PFAM

PF06624

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q3ZBR1

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613627

UniGene

Bt.102111

RefSeq

NP_001107555

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC103162

GenPept

AAI03163