InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: AK5

Summary

InnateDB Protein

IDBP-689750.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

AK5

Protein Name

Adenylate kinase isoenzyme 5

Synonyms

AK 5;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000023151

InnateDB Gene

IDBG-637718 (AK5)

Protein Structure

UniProt Annotation

Function

Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0004017	adenylate kinase activity
GO:0004550	nucleoside diphosphate kinase activity
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016740	transferase activity
GO:0019205	nucleobase-containing compound kinase activity
GO:0019206	nucleoside kinase activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006165	nucleoside diphosphate phosphorylation
GO:0009142	nucleoside triphosphate biosynthetic process
GO:0016310	phosphorylation
GO:0046034	ATP metabolic process

Cellular Component

GO:0005737	cytoplasm
GO:0005815	microtubule organizing center

Protein Structure and Domains

PDB ID

InterPro

IPR000850 Adenylate kinase/UMP-CMP kinase
IPR003117 Dimerization-anchoring domain of cAMP-dependent protein kinase, regulatory subunit
IPR006267 Adenylate kinase, isozyme 1/5
IPR007858 Dpy-30 motif
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF02197
PF05186

PRINTS

PR00094

PIRSF

SMART

SM00394

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

A4IFD0

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

613448

UniGene

Bt.92344

RefSeq

NP_001077226

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC134521

GenPept

AAI34522