Version 5.4
Bos taurus Protein: C5H22orf28
Summary
InnateDB Protein IDBP-689827.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C5H22orf28
Protein Name tRNA-splicing ligase RtcB homolog
Synonyms C22orf28; C5H22orf28; HSPC117;
Species Bos taurus
Ensembl Protein ENSBTAP00000014699
InnateDB Gene IDBG-637793 (C5H22orf28)
Protein Structure
UniProt Annotation
Function Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Cytoplasm {ECO:0000255HAMAP-Rule:MF_03144}. Note=Enters into the nucleus in case of active transcription while it accumulates in cytosol when transcription level is low. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003972 RNA ligase (ATP) activity
GO:0005524 ATP binding
GO:0008452 RNA ligase activity
GO:0016874 ligase activity
GO:0017166 vinculin binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001890 placenta development
GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation
GO:0006396 RNA processing
GO:0008033 tRNA processing
Cellular Component
GO:0005737 cytoplasm
GO:0072669 tRNA-splicing ligase complex
Protein Structure and Domains
PDB ID
InterPro IPR001233 tRNA-splicing ligase, RtcB
PFAM PF01139
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9T9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 525106
UniGene Bt.91477
RefSeq NP_001015631
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC104498 BT020831
GenPept AAI04499 AAX08848

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca