InnateDB Protein
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IDBP-68984.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SSX2
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Protein Name
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synovial sarcoma, X breakpoint 2
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000338796
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InnateDB Gene
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IDBG-408991 (SSX2)
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Protein Structure
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Function |
Could act as a modulator of transcription.
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Subcellular Localization |
Nucleus.
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Disease Associations |
Note=A chromosomal aberration involving SSX2 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
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Tissue Specificity |
Expressed at high level in the testis. Expressed at low level in thyroid. Not detected in tonsil, colon, lung, spleen, prostate, kidney, striated and smooth muscles. Detected in rhabdomyosarcoma and fibrosarcoma cell lines. Not detected in mesenchymal and epithelial cell lines.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
11
[view]
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Protein-Protein |
11
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001909
Krueppel-associated box
IPR003655
Krueppel-associated box-related
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PFAM |
PF01352
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PRINTS |
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PIRSF |
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SMART |
SM00349
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TIGRFAMs |
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Modification |
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SwissProt |
Q16385
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PhosphoSite |
PhosphoSite-Q16385
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TrEMBL |
Q9NZK4
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UniProt Splice Variant |
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Entrez Gene |
727837
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UniGene |
Hs.661107
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RefSeq |
NP_003138
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HUGO |
HGNC:11336
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OMIM |
300192
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CCDS |
CCDS14345
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HPRD |
02180
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IMGT |
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EMBL |
AF190791
AL445236
AL450023
BC002818
BC007343
BC016957
BC069313
BC071827
BC103863
S79332
S79894
X79200
X86175
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GenPept |
AAB35379
AAB35674
AAF44724
AAH02818
AAH07343
AAH16957
AAH69313
AAH71827
AAI03864
CAA60111
CAI41151
CAI41152
CAI41157
CAI41158
CAI41623
CAI41624
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