InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PLCE1

Summary

InnateDB Protein

IDBP-689841.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLCE1

Protein Name

phospholipase C, epsilon 1

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000025249

InnateDB Gene

IDBG-637752 (PLCE1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004629	phospholipase C activity
GO:0004871	signal transducer activity
GO:0005085	guanyl-nucleotide exchange factor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0019899	enzyme binding

Biological Process

GO:0000187	activation of MAPK activity
GO:0006629	lipid metabolic process
GO:0007165	signal transduction
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007264	small GTPase mediated signal transduction
GO:0008277	regulation of G-protein coupled receptor protein signaling pathway
GO:0016042	lipid catabolic process
GO:0032835	glomerulus development
GO:0035556	intracellular signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0045859	regulation of protein kinase activity
GO:0046578	regulation of Ras protein signal transduction

Cellular Component

GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000159 Ras-association
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001192 Phosphoinositide phospholipase C family
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR023578 Ras guanine nucleotide exchange factor domain
IPR029071 Ubiquitin-related domain

PFAM

PF00168
PF00788
PF00388
PF00387
PF00617
PF09279

PRINTS

PR00360
PR00390

PIRSF

SMART

SM00239
SM00314
SM00148
SM00149
SM00147

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt