InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: NUB1

Summary

InnateDB Protein

IDBP-689866.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NUB1

Protein Name

NEDD8 ultimate buster 1

Synonyms

NYREN18;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000005970

InnateDB Gene

IDBG-637824 (NUB1)

Protein Structure

UniProt Annotation

Function

Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8 and its conjugates to the proteasome for degradation (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}. Note=Predominantly nuclear. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006511	ubiquitin-dependent protein catabolic process
GO:0016567	protein ubiquitination
GO:0032436	positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0034341	response to interferon-gamma
GO:0034612	response to tumor necrosis factor

Cellular Component

GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

InterPro

IPR000449 Ubiquitin-associated domain/translation elongation factor EF-Ts, N-terminal
IPR009060 UBA-like
IPR015940 Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote
IPR029071 Ubiquitin-related domain

PFAM

PF00627

PRINTS

PIRSF

SMART

SM00165

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8MJ87