Version 5.4
Bos taurus Protein: SHMT1
Summary
InnateDB Protein IDBP-689878.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SHMT1
Protein Name serine hydroxymethyltransferase, cytosolic
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000022732
InnateDB Gene IDBG-637842 (SHMT1)
Protein Structure
UniProt Annotation
Function Interconversion of serine and glycine. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004372 glycine hydroxymethyltransferase activity
GO:0016740 transferase activity
GO:0030170 pyridoxal phosphate binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006544 glycine metabolic process
GO:0006563 L-serine metabolic process
GO:0006565 L-serine catabolic process
GO:0006730 one-carbon metabolic process
GO:0009113 purine nucleobase biosynthetic process
GO:0035999 tetrahydrofolate interconversion
GO:0046655 folic acid metabolic process
GO:0051262 protein tetramerization
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR001085 Serine hydroxymethyltransferase
IPR015424 Pyridoxal phosphate-dependent transferase
PFAM PF00464
PRINTS
PIRSF PIRSF000412
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5E9P9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 509002
UniGene Bt.88340
RefSeq NP_001015553
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112563 BT020871
GenPept AAI12564 AAX08888

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca