Version 5.4
Bos taurus Protein: FUNDC1
Summary
InnateDB Protein IDBP-689894.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FUNDC1
Protein Name FUN14 domain-containing protein 1
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000002144
InnateDB Gene IDBG-637861 (FUNDC1)
Protein Structure
UniProt Annotation
Function Acts as an activator of hypoxia-induced mitophagy, an important mechanism for mitochondrial quality control. {ECO:0000250}.
Subcellular Localization Mitochondrion outer membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0001666 response to hypoxia
GO:0006914 autophagy
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0031307 integral component of mitochondrial outer membrane
Protein Structure and Domains
PDB ID
InterPro IPR007014 FUN14
PFAM PF04930
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt F1N5S9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 518258
UniGene Bt.68214
RefSeq NP_001098452
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC150029 DAAA02073542
GenPept AAI50030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca