Version 5.4
Bos taurus Protein: NDP
Summary
InnateDB Protein IDBP-689906.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NDP
Protein Name Norrin
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000016757
InnateDB Gene IDBG-637874 (NDP)
Protein Structure
UniProt Annotation
Function Activates the canonical Wnt signaling pathway through FZD4 and LRP5 coreceptor. Plays a central role in retinal vascularization by acting as a ligand for FZD4 that signals via stabilizing beta-catenin (CTNNB1) and activating LEF/TCF-mediated transcriptional programs. Acts in concert with TSPAN12 to activate FZD4 independently of the Wnt-dependent activation of FZD4, suggesting the existence of a Wnt-independent signaling that also promote accumulation the beta-catenin (CTNNB1). May be involved in a pathway that regulates neural cell differentiation and proliferation. Possible role in neuroectodermal cell-cell interaction (By similarity). {ECO:0000250}.
Subcellular Localization Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005109 frizzled binding
GO:0005125 cytokine activity
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0001890 placenta development
GO:0016055 Wnt signaling pathway
GO:0035426 extracellular matrix-cell signaling
GO:0045893 positive regulation of transcription, DNA-templated
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0060070 canonical Wnt signaling pathway
GO:0061299 retina vasculature morphogenesis in camera-type eye
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0009986 cell surface
GO:0031012 extracellular matrix
Protein Structure and Domains
PDB ID
InterPro IPR003064 Norrie disease protein
IPR004133 DAN
IPR006207 Cystine knot, C-terminal
IPR006208 Glycoprotein hormone subunit beta, cystine knot
PFAM PF03045
PF00007
PRINTS PR01304
PIRSF
SMART SM00041
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q2KI78
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 511596
UniGene Bt.41310
RefSeq NP_001039555
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112738
GenPept AAI12739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca