Version 5.4
Bos taurus Protein: FZD8
Summary
InnateDB Protein IDBP-689941.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FZD8
Protein Name frizzled family receptor 8
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000020060
InnateDB Gene IDBG-637900 (FZD8)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0017147 Wnt-protein binding
GO:0030165 PDZ domain binding
GO:0031625 ubiquitin protein ligase binding
GO:0042813 Wnt-activated receptor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001934 positive regulation of protein phosphorylation
GO:0007166 cell surface receptor signaling pathway
GO:0007275 multicellular organismal development
GO:0016055 Wnt signaling pathway
GO:0033077 T cell differentiation in thymus
GO:0043507 positive regulation of JUN kinase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0060070 canonical Wnt signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR000539 Frizzled protein
IPR017981 GPCR, family 2-like
IPR020067 Frizzled domain
PFAM PF01534
PF01392
PRINTS PR00489
PIRSF
SMART SM00063
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BCW7
UniProt Splice Variant
Entrez Gene 616913
UniGene
RefSeq XP_005214377
HUGO HGNC:4046
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02035493 DAAA02035494
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca