Version 5.4
Bos taurus Protein: ALDH18A1
Summary
InnateDB Protein IDBP-690009.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALDH18A1
Protein Name delta-1-pyrroline-5-carboxylate synthase
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000015703
InnateDB Gene IDBG-637965 (ALDH18A1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 21 interaction(s) predicted by orthology.
Predicted by orthology
Total 21 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004349 glutamate 5-kinase activity
GO:0004350 glutamate-5-semialdehyde dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016740 transferase activity
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006536 glutamate metabolic process
GO:0006561 proline biosynthetic process
GO:0006592 ornithine biosynthetic process
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0019240 citrulline biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR000965 Gamma-glutamyl phosphate reductase GPR
IPR001048 Aspartate/glutamate/uridylate kinase
IPR001057 Glutamate/acetylglutamate kinase
IPR005766 Delta l-pyrroline-5-carboxylate synthetase
IPR015590 Aldehyde dehydrogenase domain
IPR016161 Aldehyde/histidinol dehydrogenase
PFAM PF00696
PF00171
PRINTS PR00474
PIRSF PIRSF036429
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q2KJH7
UniProt Splice Variant
Entrez Gene 514759
UniGene Bt.73294
RefSeq NP_001039646
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC105337 DAAA02058881
GenPept AAI05338

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca