Version 5.4
Bos taurus Protein: TXN2
Summary
InnateDB Protein IDBP-690080.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TXN2
Protein Name Thioredoxin, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000000014
InnateDB Gene IDBG-638041 (TXN2)
Protein Structure
UniProt Annotation
Function Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential (By similarity). Possesses a dithiol-reducing activity. Cooperates with SP-22 protein to protect glutamine synthetase and other proteins from Fe(2+) ion/dithiothreitol-mediated damage. Without SP-22, the protein had no protecting activity. {ECO:0000250}.
Subcellular Localization Mitochondrion.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0015035 protein disulfide oxidoreductase activity
Biological Process
GO:0006662 glycerol ether metabolic process
GO:0045454 cell redox homeostasis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005730 nucleolus
GO:0005739 mitochondrion
Protein Structure and Domains
PDB ID
InterPro IPR005746 Thioredoxin
IPR012336 Thioredoxin-like fold
IPR013766 Thioredoxin domain
PFAM PF13098
PF13192
PF13462
PF13905
PF00085
PRINTS
PIRSF PIRSF000077
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q95108
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 281557
UniGene Bt.5288
RefSeq NP_776633
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC112876 D87741
GenPept AAI12877 BAA13447

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca