InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: CYBB

Summary

InnateDB Protein

IDBP-690202.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYBB

Protein Name

Cytochrome b-245 heavy chain

Synonyms

NOX2;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000026580

InnateDB Gene

IDBG-638147 (CYBB)

Protein Structure

UniProt Annotation

Function

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 20 interaction(s) predicted by orthology.

Predicted by orthology
Total	20 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005244	voltage-gated ion channel activity
GO:0005515	protein binding
GO:0009055	electron carrier activity
GO:0016175	superoxide-generating NADPH oxidase activity
GO:0016491	oxidoreductase activity
GO:0020037	heme binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity
GO:0050660	flavin adenine dinucleotide binding

Biological Process

GO:0006801	superoxide metabolic process
GO:0006811	ion transport
GO:0006954	inflammatory response
GO:0034765	regulation of ion transmembrane transport
GO:0042554	superoxide anion generation
GO:0050665	hydrogen peroxide biosynthetic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043020	NADPH oxidase complex
GO:0045121	membrane raft

Protein Structure and Domains

PDB ID

InterPro

IPR000778 Cytochrome b245, heavy chain
IPR008333 Oxidoreductase, FAD-binding domain
IPR013112 FAD-binding 8
IPR013121 Ferric reductase, NAD binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR017938 Riboflavin synthase-like beta-barrel

PFAM

PF00970
PF08022
PF08030
PF01794

PRINTS

PR00466

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

O46522