Version 5.4
Bos taurus Protein: INTS7
Summary
InnateDB Protein IDBP-690230.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol INTS7
Protein Name Integrator complex subunit 7
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000024684
InnateDB Gene IDBG-638178 (INTS7)
Protein Structure
UniProt Annotation
Function Component of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Plays a role in DNA damage response (DDR) signaling during the S phase (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=Localizes to sites of DNA damage in a H2AX- independent manner. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
Predicted by orthology
Total 11 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
Biological Process
GO:0000077 DNA damage checkpoint
GO:0006974 cellular response to DNA damage stimulus
GO:0016180 snRNA processing
GO:0071479 cellular response to ionizing radiation
Cellular Component
GO:0005634 nucleus
GO:0005694 chromosome
GO:0032039 integrator complex
Protein Structure and Domains
PDB ID
InterPro IPR016024 Armadillo-type fold
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1RMS6
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 534964
UniGene Bt.37040
RefSeq NP_001069512
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC114738
GenPept AAI14739

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca