InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PDE4B

Summary

InnateDB Protein

IDBP-690317.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE4B

Protein Name

cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000011390

InnateDB Gene

IDBG-638251 (PDE4B)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115	3',5'-cyclic-AMP phosphodiesterase activity
GO:0008081	phosphoric diester hydrolase activity
GO:0016787	hydrolase activity
GO:0030552	cAMP binding
GO:0046872	metal ion binding

Biological Process

GO:0001780	neutrophil homeostasis
GO:0007165	signal transduction
GO:0008152	metabolic process
GO:0030593	neutrophil chemotaxis
GO:0032729	positive regulation of interferon-gamma production
GO:0032743	positive regulation of interleukin-2 production
GO:0035690	cellular response to drug
GO:0050852	T cell receptor signaling pathway
GO:0050900	leukocyte migration
GO:0071222	cellular response to lipopolysaccharide

Cellular Component

GO:0071944

cell periphery

Protein Structure and Domains

PDB ID

InterPro

IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF00233

PRINTS

PR00387

PIRSF

SMART

SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt