Version 5.4
Bos taurus Protein: UQCRC2
Summary
InnateDB Protein IDBP-690323.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol UQCRC2
Protein Name Cytochrome b-c1 complex subunit 2, mitochondrial
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000028853
InnateDB Gene IDBG-638256 (UQCRC2)
Protein Structure
UniProt Annotation
Function This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.
Subcellular Localization Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004222 metalloendopeptidase activity
GO:0005515 protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0005750 mitochondrial respiratory chain complex III
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
GO:0070469 respiratory chain
Protein Structure and Domains
PDB ID
InterPro IPR007863 Peptidase M16, C-terminal domain
IPR011249 Metalloenzyme, LuxS/M16 peptidase-like
IPR011765 Peptidase M16, N-terminal
PFAM PF05193
PF00675
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P23004
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 282394
UniGene Bt.63020
RefSeq NP_777055
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC102337 BT020993 X59693
GenPept AAI02338 AAX09010 CAA42214

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca