InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: POLA1

Summary

InnateDB Protein

IDBP-690436.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLA1

Protein Name

DNA polymerase

Synonyms

Species

Bos taurus

Ensembl Protein

ENSBTAP00000010742

InnateDB Gene

IDBG-638342 (POLA1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 29 interaction(s) predicted by orthology.

Predicted by orthology
Total	29 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0001882	nucleoside binding
GO:0003676	nucleic acid binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0003896	DNA primase activity
GO:0005515	protein binding
GO:0016740	transferase activity
GO:0016779	nucleotidyltransferase activity
GO:0046982	protein heterodimerization activity

Biological Process

GO:0000084	mitotic S phase
GO:0006139	nucleobase-containing compound metabolic process
GO:0006260	DNA replication
GO:0006269	DNA replication, synthesis of RNA primer
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006272	leading strand elongation
GO:0006273	lagging strand elongation
GO:0006303	double-strand break repair via nonhomologous end joining
GO:0008283	cell proliferation

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005635	nuclear envelope
GO:0005654	nucleoplasm
GO:0005658	alpha DNA polymerase:primase complex
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

InterPro

IPR006133 DNA-directed DNA polymerase, family B, exonuclease domain
IPR006134 DNA-directed DNA polymerase, family B, multifunctional domain
IPR006172 DNA-directed DNA polymerase, family B
IPR012337 Ribonuclease H-like domain
IPR015088 Zinc finger, DNA-directed DNA polymerase, family B, alpha
IPR024647 DNA polymerase alpha catalytic subunit, N-terminal domain

PFAM

PF03104
PF00136
PF08996
PF12254

PRINTS

PR00106

PIRSF

SMART

SM00486

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt