Version 5.4
Bos taurus Protein: TGFB1
Summary
InnateDB Protein IDBP-690486.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TGFB1
Protein Name transforming growth factor beta-1 precursor
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027261
InnateDB Gene IDBG-638417 (TGFB1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0003823 antigen binding
GO:0005114 type II transforming growth factor beta receptor binding
GO:0005160 transforming growth factor beta receptor binding
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0019899 enzyme binding
Biological Process
GO:0000060 protein import into nucleus, translocation
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000165 MAPK cascade
GO:0001657 ureteric bud development
GO:0001775 cell activation
GO:0001933 negative regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002028 regulation of sodium ion transport
GO:0002062 chondrocyte differentiation
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002460 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002513 tolerance induction to self antigen
GO:0006468 protein phosphorylation
GO:0006611 protein export from nucleus
GO:0006754 ATP biosynthetic process
GO:0006796 phosphate-containing compound metabolic process
GO:0006874 cellular calcium ion homeostasis
GO:0006954 inflammatory response
GO:0007050 cell cycle arrest
GO:0007093 mitotic cell cycle checkpoint
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007182 common-partner SMAD protein phosphorylation
GO:0007183 SMAD protein complex assembly
GO:0007184 SMAD protein import into nucleus
GO:0007435 salivary gland morphogenesis
GO:0007492 endoderm development
GO:0008156 negative regulation of DNA replication
GO:0008283 cell proliferation
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0008354 germ cell migration
GO:0009611 response to wounding
GO:0010628 positive regulation of gene expression
GO:0010629 negative regulation of gene expression
GO:0010718 positive regulation of epithelial to mesenchymal transition
GO:0010763 positive regulation of fibroblast migration
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0010936 negative regulation of macrophage cytokine production
GO:0016049 cell growth
GO:0016202 regulation of striated muscle tissue development
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway
GO:0019049 evasion or tolerance of host defenses by virus
GO:0022408 negative regulation of cell-cell adhesion
GO:0030214 hyaluronan catabolic process
GO:0030217 T cell differentiation
GO:0030279 negative regulation of ossification
GO:0030308 negative regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0030501 positive regulation of bone mineralization
GO:0030879 mammary gland development
GO:0031065 positive regulation of histone deacetylation
GO:0031334 positive regulation of protein complex assembly
GO:0031663 lipopolysaccharide-mediated signaling pathway
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0032740 positive regulation of interleukin-17 production
GO:0032801 receptor catabolic process
GO:0032930 positive regulation of superoxide anion generation
GO:0032943 mononuclear cell proliferation
GO:0032967 positive regulation of collagen biosynthetic process
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0035066 positive regulation of histone acetylation
GO:0035307 positive regulation of protein dephosphorylation
GO:0040007 growth
GO:0042110 T cell activation
GO:0042127 regulation of cell proliferation
GO:0042130 negative regulation of T cell proliferation
GO:0042306 regulation of protein import into nucleus
GO:0042307 positive regulation of protein import into nucleus
GO:0042482 positive regulation of odontogenesis
GO:0043011 myeloid dendritic cell differentiation
GO:0043029 T cell homeostasis
GO:0043406 positive regulation of MAP kinase activity
GO:0043491 protein kinase B signaling
GO:0043536 positive regulation of blood vessel endothelial cell migration
GO:0043537 negative regulation of blood vessel endothelial cell migration
GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity
GO:0043932 ossification involved in bone remodeling
GO:0045066 regulatory T cell differentiation
GO:0045216 cell-cell junction organization
GO:0045599 negative regulation of fat cell differentiation
GO:0045662 negative regulation of myoblast differentiation
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045930 negative regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048298 positive regulation of isotype switching to IgA isotypes
GO:0048535 lymph node development
GO:0048642 negative regulation of skeletal muscle tissue development
GO:0050680 negative regulation of epithelial cell proliferation
GO:0050714 positive regulation of protein secretion
GO:0050868 negative regulation of T cell activation
GO:0050921 positive regulation of chemotaxis
GO:0051098 regulation of binding
GO:0051101 regulation of DNA binding
GO:0051897 positive regulation of protein kinase B signaling
GO:0060325 face morphogenesis
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:0060391 positive regulation of SMAD protein import into nucleus
GO:0060744 mammary gland branching involved in thelarche
GO:0060751 branch elongation involved in mammary gland duct branching
GO:0060762 regulation of branching involved in mammary gland duct morphogenesis
GO:0061035 regulation of cartilage development
GO:0070306 lens fiber cell differentiation
GO:0070723 response to cholesterol
GO:0071158 positive regulation of cell cycle arrest
GO:0071363 cellular response to growth factor stimulus
GO:0071407 cellular response to organic cyclic compound
GO:0071560 cellular response to transforming growth factor beta stimulus
GO:0085029 extracellular matrix assembly
GO:0097191 extrinsic apoptotic signaling pathway
GO:1900126 negative regulation of hyaluronan biosynthetic process
GO:1900182 positive regulation of protein localization to nucleus
GO:1901666 positive regulation of NAD+ ADP-ribosyltransferase activity
GO:2000249 regulation of actin cytoskeleton reorganization
GO:2000628 regulation of miRNA metabolic process
GO:2000679 positive regulation of transcription regulatory region DNA binding
Cellular Component
GO:0005576 extracellular region
GO:0005578 proteinaceous extracellular matrix
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005902 microvillus
GO:0009986 cell surface
GO:0031012 extracellular matrix
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID
InterPro IPR001111 Transforming growth factor-beta, N-terminal
IPR001839 Transforming growth factor-beta, C-terminal
IPR003939 Transforming growth factor, beta 1
IPR016319 Transforming growth factor-beta
IPR029034 Cystine-knot cytokine
PFAM PF00688
PF00019
PRINTS PR01424
PR01423
PIRSF PIRSF001787
SMART SM00204
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL E1BNK3
UniProt Splice Variant
Entrez Gene 282089
UniGene Bt.469
RefSeq NP_001159540
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02047109
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca