Version 5.4
Bos taurus Protein: CACNB2
Summary
InnateDB Protein IDBP-690535.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CACNB2
Protein Name Voltage-dependent L-type calcium channel subunit beta-2
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000029344
InnateDB Gene IDBG-638455 (CACNB2)
Protein Structure
UniProt Annotation
Function The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.
Subcellular Localization Cell membrane, sarcolemma {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005244 voltage-gated ion channel activity
GO:0005245 voltage-gated calcium channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0008331 high voltage-gated calcium channel activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006816 calcium ion transport
GO:0007268 synaptic transmission
GO:0007601 visual perception
GO:0034765 regulation of ion transmembrane transport
GO:0051928 positive regulation of calcium ion transport
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005891 voltage-gated calcium channel complex
GO:0016020 membrane
GO:0042383 sarcolemma
Protein Structure and Domains
PDB ID
InterPro IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
IPR001452 SH3 domain
IPR005444 Voltage-dependent calcium channel, L-type, beta-2 subunit
IPR008145 Guanylate kinase/L-type calcium channel beta subunit
IPR027417 P-loop containing nucleoside triphosphate hydrolase
PFAM PF12052
PF00018
PF14604
PF00625
PRINTS PR01626
PR00452
PR01628
PIRSF
SMART SM00326
SM00072
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9MZL5
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 327667
UniGene Bt.91412
RefSeq NP_786983
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF174417
GenPept AAF26681

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca