InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PIK3CB

Summary

InnateDB Protein

IDBP-690602.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIK3CB

Protein Name

phosphoinositide-3-kinase, catalytic, beta polypeptide

Synonyms

PI3K; PI3Kbeta;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000009083

InnateDB Gene

IDBG-638466 (PIK3CB)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 27 interaction(s) predicted by orthology.

Predicted by orthology
Total	27 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0005488	binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016301	kinase activity
GO:0016303	1-phosphatidylinositol-3-kinase activity
GO:0016740	transferase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0016773	phosphotransferase activity, alcohol group as acceptor
GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0043560	insulin receptor substrate binding
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Biological Process

GO:0001952	regulation of cell-matrix adhesion
GO:0006874	cellular calcium ion homeostasis
GO:0007156	homophilic cell adhesion
GO:0016310	phosphorylation
GO:0030168	platelet activation
GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process
GO:0040016	embryonic cleavage
GO:0046854	phosphatidylinositol phosphorylation
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005886	plasma membrane
GO:0005942	phosphatidylinositol 3-kinase complex

Protein Structure and Domains

PDB ID

InterPro

IPR000008 C2 domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR003113 Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain
IPR011009 Protein kinase-like domain
IPR016024 Armadillo-type fold
IPR029071 Ubiquitin-related domain

PFAM

PF00168
PF00794
PF00454
PF00613
PF00792
PF02192

PRINTS

PR00360

PIRSF

SMART

SM00239
SM00144
SM00146
SM00145
SM00142
SM00143

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt