InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: GOT1

Summary

InnateDB Protein

IDBP-690635.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GOT1

Protein Name

Aspartate aminotransferase, cytoplasmic

Synonyms

cAspAT; cCAT;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000015873

InnateDB Gene

IDBG-638559 (GOT1)

Protein Structure

UniProt Annotation

Function

Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity
GO:0004609	phosphatidylserine decarboxylase activity
GO:0008483	transaminase activity
GO:0016740	transferase activity
GO:0030170	pyridoxal phosphate binding
GO:0047801	L-cysteine:2-oxoglutarate aminotransferase activity
GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity

Biological Process

GO:0006107	oxaloacetate metabolic process
GO:0006114	glycerol biosynthetic process
GO:0006520	cellular amino acid metabolic process
GO:0006532	aspartate biosynthetic process
GO:0006533	aspartate catabolic process
GO:0008652	cellular amino acid biosynthetic process
GO:0009058	biosynthetic process
GO:0019550	glutamate catabolic process to aspartate
GO:0019551	glutamate catabolic process to 2-oxoglutarate
GO:0032869	cellular response to insulin stimulus
GO:0051384	response to glucocorticoid
GO:0055089	fatty acid homeostasis

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000796 Aspartate/other aminotransferase
IPR004839 Aminotransferase, class I/classII
IPR015424 Pyridoxal phosphate-dependent transferase

PFAM

PF00155

PRINTS

PR00799

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P33097

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

281206

UniGene

Bt.17296

RefSeq

NP_803468

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

BC105372 BT020856 X66020

GenPept

AAI05373 AAX08873 CAA46818