InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Protein: PTHLH

Summary

InnateDB Protein

IDBP-690661.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PTHLH

Protein Name

Parathyroid hormone-related proteinOsteostatin

Synonyms

PTHrP;

Species

Bos taurus

Ensembl Protein

ENSBTAP00000040744

InnateDB Gene

IDBG-638592 (PTHLH)

Protein Structure

UniProt Annotation

Function

Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). {ECO:0000250}.Osteostatin is a potent inhibitor of osteoclastic bone resorption. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in the mammary gland.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005179	hormone activity
GO:0051428	peptide hormone receptor binding

Biological Process

GO:0001501	skeletal system development
GO:0001958	endochondral ossification
GO:0002076	osteoblast development
GO:0007189	adenylate cyclase-activating G-protein coupled receptor signaling pathway
GO:0007492	endoderm development
GO:0008284	positive regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0016485	protein processing
GO:0030819	positive regulation of cAMP biosynthetic process
GO:0030855	epithelial cell differentiation
GO:0032330	regulation of chondrocyte differentiation
GO:0032331	negative regulation of chondrocyte differentiation
GO:0043129	surfactant homeostasis
GO:0043433	negative regulation of sequence-specific DNA binding transcription factor activity
GO:0048286	lung alveolus development
GO:0060649	mammary gland bud elongation
GO:0060659	nipple sheath formation

Cellular Component

GO:0005576	extracellular region
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus

Protein Structure and Domains

PDB ID

InterPro

IPR001415 Parathyroid hormone/parathyroid hormone-related protein

PFAM

PF01279

PRINTS

PIRSF

SMART

SM00087

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P58073

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

286767

UniGene

Bt.12848

RefSeq

XP_005206971

HUGO

OMIM

CCDS

HPRD

IMGT

EMBL

AB097837 BC149411

GenPept

AAI49412 BAC44840