Version 5.4
Bos taurus Protein: PTHLH
Summary
InnateDB Protein IDBP-690663.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTHLH
Protein Name Parathyroid hormone-related proteinOsteostatin
Synonyms PTHrP;
Species Bos taurus
Ensembl Protein ENSBTAP00000008581
InnateDB Gene IDBG-638592 (PTHLH)
Protein Structure
UniProt Annotation
Function Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Upregulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath (By similarity). {ECO:0000250}.Osteostatin is a potent inhibitor of osteoclastic bone resorption. {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Secreted {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in the mammary gland.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0051428 peptide hormone receptor binding
Biological Process
GO:0032330 regulation of chondrocyte differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID
InterPro IPR001415 Parathyroid hormone/parathyroid hormone-related protein
PFAM PF01279
PRINTS
PIRSF
SMART SM00087
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P58073
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 286767
UniGene Bt.12848
RefSeq NP_777178
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AB097837 BC149411
GenPept AAI49412 BAC44840

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca