Version 5.4
Bos taurus Protein: GSK3A
Summary
InnateDB Protein IDBP-690684.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GSK3A
Protein Name glycogen synthase kinase-3 alpha
Synonyms
Species Bos taurus
Ensembl Protein ENSBTAP00000027660
InnateDB Gene IDBG-638599 (GSK3A)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 39 interaction(s) predicted by orthology.
Predicted by orthology
Total 39 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0003073 regulation of systemic arterial blood pressure
GO:0003214 cardiac left ventricle morphogenesis
GO:0006349 regulation of gene expression by genetic imprinting
GO:0006468 protein phosphorylation
GO:0008286 insulin receptor signaling pathway
GO:0010800 positive regulation of peptidyl-threonine phosphorylation
GO:0016477 cell migration
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0032007 negative regulation of TOR signaling
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0036016 cellular response to interleukin-3
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0044027 hypermethylation of CpG island
GO:0045823 positive regulation of heart contraction
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development
GO:0071285 cellular response to lithium ion
GO:0071407 cellular response to organic cyclic compound
GO:0071879 positive regulation of adrenergic receptor signaling pathway
GO:0097192 extrinsic apoptotic signaling pathway in absence of ligand
GO:1901030 positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO:2000467 positive regulation of glycogen (starch) synthase activity
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF07714
PRINTS PR00109
PIRSF
SMART SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A6QLB8
UniProt Splice Variant
Entrez Gene 536561
UniGene Bt.33944
RefSeq NP_001095662
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC147908 DAAA02047214 DAAA02047215
GenPept AAI47909

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca