InnateDB Protein
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IDBP-690781.2
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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SLC5A11
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Protein Name
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Sodium/myo-inositol cotransporter 2
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Synonyms
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SMIT2;
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Species
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Bos taurus
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Ensembl Protein
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ENSBTAP00000004510
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InnateDB Gene
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IDBG-638688 (SLC5A11)
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Protein Structure
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Function |
Involved in the sodium-dependent cotransport of myo- inositol (MI) with a Na(+):MI stoichiometry of 2:1. Exclusively responsible for apical MI transport and absorption in intestine. Also can transport D-chiro-inositol (DCI) but not L-fructose. Exhibits stereospecific cotransport of both D-glucose and D- xylose. May induce apoptosis through the TNF-alpha, PDCD1 pathway. May play a role in the regulation of MI concentration in serum, involving reabsorption in at least the proximal tubule of the kidney.
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Subcellular Localization |
Membrane {ECO:0000250UniProtKB:Q28728}; Multi-pass membrane protein {ECO:0000250UniProtKB:Q28728}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001734
Sodium/solute symporter
IPR019900
Sodium/solute symporter, subgroup
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PFAM |
PF00474
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q3ZC26
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
539084
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UniGene |
Bt.49470
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RefSeq |
NP_001029832
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HUGO |
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
BC102962
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GenPept |
AAI02963
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