Version 5.4
Bos taurus Protein: PTPRC
Summary
InnateDB Protein IDBP-690818.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTPRC
Protein Name protein tyrosine phosphatase, receptor type, C
Synonyms cd45;
Species Bos taurus
Ensembl Protein ENSBTAP00000013320
InnateDB Gene IDBG-638670 (PTPRC)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 53 interaction(s) predicted by orthology.
Predicted by orthology
Total 53 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004725 protein tyrosine phosphatase activity
GO:0005515 protein binding
GO:0008201 heparin binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0019901 protein kinase binding
GO:0043395 heparan sulfate proteoglycan binding
Biological Process
GO:0000187 activation of MAPK activity
GO:0001915 negative regulation of T cell mediated cytotoxicity
GO:0001916 positive regulation of T cell mediated cytotoxicity
GO:0001960 negative regulation of cytokine-mediated signaling pathway
GO:0002244 hematopoietic progenitor cell differentiation
GO:0002378 immunoglobulin biosynthetic process
GO:0002711 positive regulation of T cell mediated immunity
GO:0002923 regulation of humoral immune response mediated by circulating immunoglobulin
GO:0002925 positive regulation of humoral immune response mediated by circulating immunoglobulin
GO:0006470 protein dephosphorylation
GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration
GO:0007159 leukocyte cell-cell adhesion
GO:0016311 dephosphorylation
GO:0030183 B cell differentiation
GO:0030217 T cell differentiation
GO:0030890 positive regulation of B cell proliferation
GO:0031953 negative regulation of protein autophosphorylation
GO:0034113 heterotypic cell-cell adhesion
GO:0042098 T cell proliferation
GO:0042100 B cell proliferation
GO:0042102 positive regulation of T cell proliferation
GO:0043410 positive regulation of MAPK cascade
GO:0044770 cell cycle phase transition
GO:0045059 positive thymic T cell selection
GO:0045060 negative thymic T cell selection
GO:0045577 regulation of B cell differentiation
GO:0045582 positive regulation of T cell differentiation
GO:0045588 positive regulation of gamma-delta T cell differentiation
GO:0046641 positive regulation of alpha-beta T cell proliferation
GO:0048304 positive regulation of isotype switching to IgG isotypes
GO:0048539 bone marrow development
GO:0048864 stem cell development
GO:0050732 negative regulation of peptidyl-tyrosine phosphorylation
GO:0050852 T cell receptor signaling pathway
GO:0050853 B cell receptor signaling pathway
GO:0050855 regulation of B cell receptor signaling pathway
GO:0050857 positive regulation of antigen receptor-mediated signaling pathway
GO:0051209 release of sequestered calcium ion into cytosol
GO:0051607 defense response to virus
GO:0051726 regulation of cell cycle
GO:2000473 positive regulation of hematopoietic stem cell migration
GO:2000648 positive regulation of stem cell proliferation
GO:2001236 regulation of extrinsic apoptotic signaling pathway
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0009897 external side of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
GO:0071944 cell periphery
Protein Structure and Domains
PDB ID
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
IPR000387 Protein-tyrosine/Dual specificity phosphatase
IPR003595 Protein-tyrosine phosphatase, catalytic
IPR003961 Fibronectin, type III
IPR016335 Leukocyte common antigen
IPR029021 Protein-tyrosine phosphatase-like
PFAM PF00102
PF00041
PF01108
PF12567
PRINTS PR00700
PIRSF PIRSF002004
SMART SM00194
SM00404
SM00060
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL F1MJS9
UniProt Splice Variant
Entrez Gene 407152
UniGene
RefSeq NP_001193452
HUGO HGNC:9666
OMIM
CCDS
HPRD
IMGT
EMBL DAAA02043927 DAAA02043928 DAAA02043929
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca