Bos taurus Protein: GAPVD1 | |||||||||||||
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Summary | |||||||||||||
InnateDB Protein | IDBP-690844.2 | ||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||
Gene Symbol | GAPVD1 | ||||||||||||
Protein Name | GTPase-activating protein and VPS9 domain-containing protein 1 | ||||||||||||
Synonyms | |||||||||||||
Species | Bos taurus | ||||||||||||
Ensembl Protein | ENSBTAP00000015341 | ||||||||||||
InnateDB Gene | IDBG-638740 (GAPVD1) | ||||||||||||
Protein Structure | |||||||||||||
UniProt Annotation | |||||||||||||
Function | Acts both as a GTPase-activating protein (GAP) and a guanine nucleotide exchange factor (GEF), and participates in various processes such as endocytosis, insulin receptor internalization or LC2A4/GLUT4 trafficking. Acts as a GEF for the Ras-related protein RAB31 by exchanging bound GDP for free GTP, leading to regulate LC2A4/GLUT4 trafficking. In the absence of insulin, it maintains RAB31 in an active state and promotes a futile cycle between LC2A4/GLUT4 storage vesicles and early endosomes, retaining LC2A4/GLUT4 inside the cells. Upon insulin stimulation, it is translocated to the plasma membrane, releasing LC2A4/GLUT4 from intracellular storage vesicles. Also involved in EGFR trafficking and degradation, possibly by promoting EGFR ubiquitination and subsequent degradation by the proteasome. Has GEF activity for Rab5 and GAP activity for Ras (By similarity). {ECO:0000250}. | ||||||||||||
Subcellular Localization | Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome {ECO:0000250}. Note=Recruited to the plasma membrane by TRIP10/CIP4 in response to insulin. {ECO:0000250}. | ||||||||||||
Disease Associations | |||||||||||||
Tissue Specificity | |||||||||||||
Comments | |||||||||||||
Interactions | |||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||
PDB ID | |||||||||||||
InterPro |
IPR001936
Ras GTPase-activating protein IPR003123 Vacuolar sorting protein 9 IPR008936 Rho GTPase activation protein IPR013995 Vacuolar sorting protein 9, subgroup |
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PFAM |
PF00616
PF02204 |
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PRINTS | |||||||||||||
PIRSF | |||||||||||||
SMART |
SM00323
SM00167 |
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TIGRFAMs | |||||||||||||
Post-translational Modifications | |||||||||||||
Modification | |||||||||||||
Cross-References | |||||||||||||
SwissProt | A5D794 | ||||||||||||
PhosphoSite | PhosphoSite- | ||||||||||||
TrEMBL | |||||||||||||
UniProt Splice Variant | |||||||||||||
Entrez Gene | 539646 | ||||||||||||
UniGene | Bt.20982 | ||||||||||||
RefSeq | NP_001095990 | ||||||||||||
HUGO | |||||||||||||
OMIM | |||||||||||||
CCDS | |||||||||||||
HPRD | |||||||||||||
IMGT | |||||||||||||
EMBL | BC140474 | ||||||||||||
GenPept | AAI40475 | ||||||||||||