Version 5.4
Bos taurus Protein: SCD
Summary
InnateDB Protein IDBP-690856.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCD
Protein Name Acyl-CoA desaturase
Synonyms SCD1;
Species Bos taurus
Ensembl Protein ENSBTAP00000056263
InnateDB Gene IDBG-638759 (SCD)
Protein Structure
UniProt Annotation
Function Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0004768 stearoyl-CoA 9-desaturase activity
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water
Biological Process
GO:0006629 lipid metabolic process
GO:0006631 fatty acid metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID
InterPro IPR005804 Fatty acid desaturase, type 1
IPR015876 Fatty acid desaturase, type 1, core
PFAM PF00487
PRINTS PR00075
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9TT94
PhosphoSite PhosphoSite-
TrEMBL Q3YMR4
UniProt Splice Variant
Entrez Gene 280924
UniGene Bt.65021
RefSeq NP_776384
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL AF188710 AF481915 AF481916 AF481917 AF481918 AF481919 AY241932 AY241933 BC112700 DAAA02058969 DQ069781 DQ069782 DQ069783
GenPept AAF22305 AAI12701 AAL99940 AAO63569 AAO63570 AAZ73612 AAZ73613

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca