Version 5.4
Bos taurus Protein: KDM8
Summary
InnateDB Protein IDBP-690869.2
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KDM8
Protein Name Lysine-specific demethylase 8
Synonyms JMJD5;
Species Bos taurus
Ensembl Protein ENSBTAP00000026023
InnateDB Gene IDBG-638771 (KDM8)
Protein Structure
UniProt Annotation
Function Histone demethylase required for G2/M phase cell cycle progression. Specifically demethylates dimethylated 'Lys-36' (H3K36me2) of histone H3, an epigenetic repressive mark, thereby acting as a transcription activator. Regulates expression of CCNA1 (cyclin-A1) (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0003682 chromatin binding
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0051213 dioxygenase activity
GO:0051864 histone demethylase activity (H3-K36 specific)
Biological Process
GO:0000086 G2/M transition of mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007049 cell cycle
GO:0008150 biological_process
GO:0016568 chromatin modification
GO:0045893 positive regulation of transcription, DNA-templated
GO:0055114 oxidation-reduction process
GO:0070544 histone H3-K36 demethylation
Cellular Component
GO:0005575 cellular_component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID
InterPro IPR003347 JmjC domain
PFAM PF02373
PF08007
PRINTS
PIRSF
SMART SM00558
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q1JP61
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 507905
UniGene Bt.45836
RefSeq NP_001068807
HUGO
OMIM
CCDS
HPRD
IMGT
EMBL BC123879 BT025493
GenPept AAI23880 ABF57449

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca